Complement factor B deficiency associated with recurrent asceptic meningitis
نویسندگان
چکیده
Background We report complement factor B deficiency in a 16-y-old Caucasian girl, who presented with recurrent episodes of aseptic meningitis. She presented with a 2-week history of headache, vomiting, neck stiffness, facial palsy, equilibrium problems, diplopia, and low grade temperature. 4 months prior to admission she presented with a leucocytoclastic vasculitis. MRI of the brain revealed globally abnormal signal intensity in the cerebral cortex of cerebrum and cerebellum. CSF WCC was 81/μL, without rise in glucose and proteins. The patient was successfully treated with high dose glucocorticoids, but tapering of dose was followed by recurrence of the symptoms. Clinical remission was achieved with plasmapheresis, corticosteroids and mofetil mycophenolate.
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